RNF139
Reaktivität: Maus
WB, IF (cc), IF (p)
Wirt: Kaninchen
Polyclonal
AbBy Fluor® 647
Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
50 % glycerol
Handhabung
Aliquot to avoid repeated freezing and thawing.
Lagerung
-20 °C
Informationen zur Lagerung
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Lee, Brauweiler, Rudolph, Hooper, Drabkin, Gemmill: "The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways." in: Molecular cancer research : MCR, Vol. 8, Issue 1, pp. 93-106, (2010) (PubMed).
Irisawa, Inoue, Ozawa, Mori, Sato et al.: "The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces ..." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28995-9004, (2009) (PubMed).
Stagg, Thomas, van den Boomen, Wiertz, Drabkin, Gemmill, Lehner: "The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER." in: The Journal of cell biology, Vol. 186, Issue 5, pp. 685-92, (2009) (PubMed).
Brauweiler, Lorick, Lee, Tsai, Chan, Weissman, Drabkin, Gemmill: "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene." in: Oncogene, Vol. 26, Issue 16, pp. 2263-71, (2007) (PubMed).