Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

SIX3 Antikörper (AA 1-32)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SIX3 in WB. Er zeigt eine Reaktivität gegenüber Maus und Ratte.
Produktnummer ABIN5647434

Kurzübersicht für SIX3 Antikörper (AA 1-32) (ABIN5647434)

Target

Alle SIX3 Antikörper anzeigen
SIX3 (Sine Oculis-Related Homeobox 3 (SIX3))

Reaktivität

  • 37
  • 13
  • 8
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
Maus, Ratte

Wirt

  • 36
  • 3
  • 2
  • 1
Kaninchen

Klonalität

  • 40
  • 2
Polyklonal

Konjugat

  • 23
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser SIX3 Antikörper ist unkonjugiert

Applikation

  • 41
  • 19
  • 13
  • 13
  • 5
  • 4
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 15
    • 8
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-32

    Kreuzreaktivität (Details)

    Expected species reactivity: Human

    Aufreinigung

    Antigen affinity purified

    Immunogen

    Amino acids 1-32 (MVFRSPLDLYSSHFLLPNFADSHHRSILLASS) were used as the immunogen for the Six3 antibody.

    Isotyp

    IgG
  • Applikationshinweise

    Optimal dilution of the Six3 antibody should be determined by the researcher.\. Western Blot: 0.5-1 μg/mL

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    Lagerung

    -20 °C

    Informationen zur Lagerung

    After reconstitution, the Six3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target

    SIX3 (Sine Oculis-Related Homeobox 3 (SIX3))

    Andere Bezeichnung

    Six3

    Hintergrund

    Homeobox protein SIX3 is a protein that in humans is encoded by the SIX3 gene. This gene encodes a member of the sine oculishomeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in SIX3 are the cause of a severe brain malformation, called holoprosencephaly type 2 (HPE2). In HPE2, the brain fails to separate into two hemispheres during early embryonic development, leading to eye and brain malformations, which result in serious facial abnormalities. A mutant zebrafish knockout model has been developed, in which the anterior part of the head was missing due to the atypical increase of Wnt1 activity. When injected with SIX3, these zebrafish embryos were able to successfully develop a normal forebrain. When SIX3 was turned off in mice, resulting in a lack of retina formation due to excessive expression of Wnt8b in the region where the forebrain normally develops. Both of these studies demonstrate the importance of SIX3 activity in brain and eye development.

    UniProt

    O95343

    Pathways

    Protein targeting to Nucleus
Sie sind hier:
Chat with us!