Thrombopoietin Antikörper

Produktnummer ABIN5647289

Der Kaninchen Polyklonal anti-Thrombopoietin Antikörper (ABIN5647289) detektiert spezifisch Thrombopoietin in WB, ELISA und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Ratte und Maus.

Kurzübersicht für Thrombopoietin Antikörper (ABIN5647289)

Target: Thrombopoietin (THPO)

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Thrombopoietin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Thrombopoietin Antikörper

Aufreinigung: Antigen affinity purified

Immunogen: Amino acids S22-H259 from the mouse protein were used as the immunogen for the Thrombopoietin antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Thrombopoietin antibody should be determined by the researcher.\. WB: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL,ELISA: 0.1-0.5 μg/mL (mouse protein tested, request BSA-free format for coating)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Thrombopoietin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu Thrombopoietin

Target: Thrombopoietin (THPO)

Andere Bezeichnung: Thrombopoietin / THPO

Hintergrund: Thrombopoietin (THPO), also known as megakaryocyte growth and development factor (MGDF), is a protein that in humans is encoded by the THPO gene. Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent.

UniProt: P40226

Pathways: JAK-STAT Signalweg, Hormone Activity