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MUTYH Antikörper (AA 436-535)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch MUTYH in WB, ELISA, IP und RNAi. Er zeigt eine Reaktivität gegenüber Human und wurde in 7+ Publikationen erwähnt.
Produktnummer ABIN561883

Kurzübersicht für MUTYH Antikörper (AA 436-535) (ABIN561883)

Target

Alle MUTYH Antikörper anzeigen
MUTYH (MutY Homolog (E. Coli) (MUTYH))

Reaktivität

  • 56
  • 32
  • 14
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Human

Wirt

  • 49
  • 4
  • 3
Maus

Klonalität

  • 52
  • 4
Monoklonal

Konjugat

  • 35
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MUTYH Antikörper ist unkonjugiert

Applikation

  • 32
  • 18
  • 17
  • 13
  • 13
  • 13
  • 12
  • 7
  • 7
  • 6
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), ELISA, Immunoprecipitation (IP), RNA Interference (RNAi)

Klon

4D10
  • Bindungsspezifität

    • 16
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 436-535

    Verwendungszweck

    Mouse monoclonal antibody raised against a partial recombinant MUTYH.

    Sequenz

    KLTYQVYGLA LEGQTPVTTV PPGARWLTQE EFHTAAVSTA MKKVFRVYQG QQPGTCMGSK RSQVSSPCSR KKPRMGQQVL DNFFRSHIST DAHSLNSAAQ

    Kreuzreaktivität

    Human

    Produktmerkmale

    Antibody Reactive Against Recombinant Protein.

    Immunogen

    MUTYH (AAH03178, 436 a.a. ~ 535 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

    Isotyp

    IgG1
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    In 1x PBS, pH 7.4

    Handhabung

    Aliquot to avoid repeated freezing and thawing.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Komine, Shimodaira, Takao, Soeda, Zhang, Takahashi, Ishioka: "Functional Complementation Assay for 47 MUTYH Variants in a MutY-Disrupted Escherichia Coli Strain." in: Human mutation, Vol. 36, Issue 7, pp. 704-11, (2015) (PubMed).

    Shinmura, Goto, Tao, Kato, Suzuki, Nakamura, Matsuda, Yin, Morita, Kono, Sugimura: "Impaired 8-hydroxyguanine repair activity of MUTYH variant p.Arg109Trp found in a Japanese patient with early-onset colorectal cancer." in: Oxidative medicine and cellular longevity, Vol. 2014, pp. 617351, (2014) (PubMed).

    Agustina, Hahm, Han, Tran, Chung, Park, Park, Han: "Visualization of the physical and functional interaction between hMYH and hRad9 by Dronpa bimolecular fluorescence complementation." in: BMC molecular biology, Vol. 15, pp. 17, (2014) (PubMed).

    Raetz, Xie, Kundu, Brinkmeyer, Chang, David: "Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells." in: Carcinogenesis, Vol. 33, Issue 11, pp. 2301-9, (2012) (PubMed).

    Hahm, Chung, Agustina, Han, Yoon, Park, Kang, Park, Na, Han: "Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells." in: Oncology letters, Vol. 4, Issue 6, pp. 1203-1208, (2012) (PubMed).

    Suzuki, Harashima, Kamiya: "Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine." in: DNA repair, Vol. 9, Issue 5, pp. 542-50, (2010) (PubMed).

    van der Post, Kets, Ligtenberg, van Krieken, Hoogerbrugge: "Immunohistochemistry is not an accurate first step towards the molecular diagnosis of MUTYH-associated polyposis." in: Virchows Archiv : an international journal of pathology, Vol. 454, Issue 1, pp. 25-9, (2008) (PubMed).

  • Target

    MUTYH (MutY Homolog (E. Coli) (MUTYH))

    Andere Bezeichnung

    MUTYH

    Hintergrund

    Full Gene Name: mutY homolog (E. coli)
    Synonyms: MGC4416,MYH

    Gen-ID

    4595

    Pathways

    DNA Reparatur
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