HMGB1 Antikörper (AA 1-215)

Produktnummer ABIN561281

Der Maus Monoklonal Anti-HMGB1-Antikörper wurde für WB, ELISA, IF und IHC (p) validiert. Er ist geeignet, HMGB1 in Proben von Human zu detektieren. Es sind 5+ Publikationen verfügbar.

Kurzübersicht für HMGB1 Antikörper (AA 1-215) (ABIN561281)

Target: HMGB1 (High Mobility Group Box 1 (HMGB1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HMGB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 1D5

Produktdetails anti-HMGB1 Antikörper

Bindungsspezifität: AA 1-215

Verwendungszweck: Mouse monoclonal antibody raised against a full length recombinant HMGB1.

Sequenz: MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEED EEDEEDEEEE EDEEDEDEEE DDDDE

Kreuzreaktivität: Human

Produktmerkmale: Antibody Reactive Against Recombinant Protein.

Immunogen: HMGB1 (AAH03378.1, 1 a.a. ~ 215 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1x PBS, pH 7.4

Handhabung: Aliquot to avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-HMGB1 Antikörper (ABIN561281)

Ko, Hsu, Hsieh, Lien, Lee, Kou: "High expression of high-mobility group box 1 in the blood and lungs is associated with the development of chronic obstructive pulmonary disease in smokers." in: Respirology (Carlton, Vic.), Vol. 19, Issue 2, pp. 253-61, (2014) (PubMed).

Demoulin, Herfs, Somja, Roncarati, Delvenne, Hubert: "HMGB1 secretion during cervical carcinogenesis promotes the acquisition of a tolerogenic functionality by plasmacytoid dendritic cells." in: International journal of cancer. Journal international du cancer, (2014) (PubMed).

Hirano, Yoshioka, Yunoue, Fujio, Yonezawa, Niiro, Habu, Oyoshi, Sugata, Kamezawa, Arimura, Hanaya, Tokimura, Tokudome, Arita: "TLR4, IL-6, IL-18, MyD88 and HMGB1 are highly expressed in intracranial inflammatory lesions and the IgG4/IgG ratio correlates with TLR4 and IL-6." in: Neuropathology : official journal of the Japanese Society of Neuropathology, Vol. 32, Issue 6, pp. 628-37, (2012) (PubMed).

Krüger, Krick, Dhillon, Lerner, Ames, Bromberg, Lin, Walsh, Vella, Fischereder, Krämer, Colvin, Heeger, Murphy, Schröppel: "Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 9, pp. 3390-5, (2009) (PubMed).

Kijanka, Hector, Kay, Murray, Cummins, Murphy, MacCraith, Prehn, Kenny: "Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer." in: Gut, Vol. 59, Issue 1, pp. 69-78, (2009) (PubMed).

Details zu HMGB1

Target: HMGB1 (High Mobility Group Box 1 (HMGB1))

Andere Bezeichnung: HMGB1

Hintergrund: Full Gene Name: high-mobility group box 1
Synonyms: DKFZp686A04236,HMG1,HMG3,SBP-1

Gen-ID: 3146

Pathways: p53 Signalweg, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome