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APAF1 Antikörper (C-Term)
APAF1
Reaktivität: Human, Maus, Ratte
IHC (p)
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN5611436
Produktdetails anti-APAF1 Antikörper
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Target
Alle APAF1 Antikörper anzeigen
APAF1
(Apoptotic Peptidase Activating Factor 1 (APAF1))
Bindungsspezifität
Alle Epitope für APAF1 Antikörper
C-Term
Reaktivität
Alle Reaktivitäten für APAF1 Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für APAF1 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für APAF1 Antikörper
Polyklonal
Konjugat
Alle Konjugate für APAF1 Antikörper
Dieser APAF1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für APAF1 Antikörper
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Spezifität
This antibody reacts to Apoptotic Protease Activating Factor 1 (APAF1).
Aufreinigung
Immunoaffinity Chromatography
Immunogen
APAF1 antibody was raised against a synthetic peptide derived from the C-terminus of human Apaf-1 Genename: APAF1
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Buffer
10 mM PBS, pH 7.4, BSA, sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Details zu APAF1
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Target
APAF1
(Apoptotic Peptidase Activating Factor 1 (APAF1))
Andere Bezeichnung
APAF1 (APAF1 Produkte )
Synonyme
APAF1 antikoerper, ARK antikoerper, Apaf-1 antikoerper, Apaf1 antikoerper, CG6829 antikoerper, D-Apaf-1 antikoerper, DARK antikoerper, Dapaf-1 antikoerper, Dapaf-1/HAC-1 antikoerper, Dark antikoerper, Dark/Apaf-I antikoerper, Dark/Dapaf-1/HAC1 antikoerper, Dark/Hac-1/dApaf-1 antikoerper, Dark/Hac-1/dApaf1 antikoerper, Dmel\\CG6829 antikoerper, Hac-1 antikoerper, Hac-1/Dark antikoerper, Hac1 antikoerper, T1 antikoerper, anon-53Fa antikoerper, apaf-1 antikoerper, apaf1 antikoerper, arc antikoerper, ark antikoerper, dAPAF-1 antikoerper, dApaf-1 antikoerper, dApaf-1/DARK/HAC-1 antikoerper, dApaf1 antikoerper, dArk antikoerper, dapaf antikoerper, dapaf-1 antikoerper, dapaf-1L antikoerper, dapaf-1S antikoerper, dark antikoerper, dark/dapaf-1/hac-1 antikoerper, dark/hac-1/dapaf-1 antikoerper, hac-1 antikoerper, hac1 antikoerper, l(2)SH0173 antikoerper, APAF-1 antikoerper, CED4 antikoerper, 6230400I06Rik antikoerper, Apaf1l antikoerper, fog antikoerper, mKIAA0413 antikoerper, zgc:136543 antikoerper, Death-associated APAF1-related killer antikoerper, apoptotic peptidase activating factor 1 L homeolog antikoerper, apoptotic peptidase activating factor 1 antikoerper, Dark antikoerper, apaf1.L antikoerper, apaf1 antikoerper, APAF1 antikoerper, Apaf1 antikoerper
Hintergrund
Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos display an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer.Synonyms: Apaf-1, Apoptotic protease-activating factor 1, KIAA0413
Gen-ID
317
NCBI Accession
NP_001151
UniProt
O14727
Pathways
p53 Signalweg , Apoptose , Caspase Kaskade in der Apoptose , Tube Formation , Positive Regulation of Endopeptidase Activity
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