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APC2 Antikörper (AA 2041-2181)

APC2 Reaktivität: Human WB, ELISA, IHC, ICC, FACS Wirt: Maus Monoclonal 3A2G2 unconjugated
Produktnummer ABIN5611232
  • Target Alle APC2 Antikörper anzeigen
    APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))
    Bindungsspezifität
    • 15
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2041-2181
    Reaktivität
    • 28
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 28
    Maus
    Klonalität
    • 28
    Monoklonal
    Konjugat
    • 11
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser APC2 Antikörper ist unkonjugiert
    Applikation
    • 13
    • 13
    • 9
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of human APC2 (AA: 2041-2181) expressed in E. coli.
    Klon
    3A2G2
    Isotyp
    IgG1
  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400, IHC: 1:200 - 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • Target
    APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))
    Andere Bezeichnung
    APC2 (APC2 Produkte)
    Synonyme
    APCL antikoerper, AI852447 antikoerper, R75424 antikoerper, APC2, WNT signaling pathway regulator antikoerper, adenomatosis polyposis coli 2 antikoerper, APC2 antikoerper, Apc2 antikoerper
    Hintergrund

    Description: This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms.

    Aliases: APCL

    Molekulargewicht
    244 kDa
    Gen-ID
    10297
    HGNC
    10297
    Pathways
    WNT Signalweg
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