MPL Antikörper (AA 26-175)

Produktnummer ABIN5611182

Der Maus Monoklonal Anti-MPL-Antikörper wurde für FACS und ELISA validiert. Er ist geeignet, MPL in Proben von Human zu detektieren.

Kurzübersicht für MPL Antikörper (AA 26-175) (ABIN5611182)

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MPL Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA

Klon: 1D6B7

Produktdetails anti-MPL Antikörper

Bindungsspezifität: AA 26-175

Verwendungszweck: CD110 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human CD110 (AA: 26-175) expressed in E. Coli.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu MPL

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Andere Bezeichnung: CD110

Hintergrund: In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Molekulargewicht: 71.2 kDa

Gen-ID: 4352

UniProt: P40238

Pathways: JAK-STAT Signalweg