Metabotropic Glutamate Receptor 3 Antikörper (AA 433-576)

Produktnummer ABIN5611176

Der Maus Monoklonal Anti-Metabotropic Glutamate Receptor 3-Antikörper wurde für ELISA, IHC und FACS validiert. Er ist geeignet, Metabotropic Glutamate Receptor 3 in Proben von Human zu detektieren.

Kurzübersicht für Metabotropic Glutamate Receptor 3 Antikörper (AA 433-576) (ABIN5611176)

Target: Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Metabotropic Glutamate Receptor 3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Klon: 6H10C3

Produktdetails anti-Metabotropic Glutamate Receptor 3 Antikörper

Bindungsspezifität: AA 433-576

Verwendungszweck: GRM3 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human GRM3 (AA: 433-576) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu Metabotropic Glutamate Receptor 3

Target: Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))

Andere Bezeichnung: GRM3

Hintergrund: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Molekulargewicht: 99 kDa

Gen-ID: 2913

UniProt: Q14832

Pathways: cAMP Metabolic Process, Synaptic Membrane