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IGHM Antikörper (AA 310-452)

This anti-IGHM antibody (ABIN5611170) is a Mouse Monoclonal antibody detecting IGHM in IHC, WB, FACS, ELISA. Suitable for Human.
Produktnummer ABIN5611170

Kurzübersicht für IGHM Antikörper (AA 310-452) (ABIN5611170)

Target

IGHM (Immunoglobulin Heavy Constant mu (IGHM))

Reaktivität

  • 27
  • 1
  • 1
Human

Wirt

  • 14
  • 13
Maus

Klonalität

  • 17
  • 10
Monoklonal

Konjugat

  • 23
  • 1
  • 1
  • 1
  • 1
Dieser IGHM Antikörper ist unkonjugiert

Applikation

  • 14
  • 13
  • 11
  • 7
  • 7
  • 7
  • 6
  • 4
  • 2
  • 1
  • 1
Immunohistochemistry (IHC), Western Blotting (WB), Flow Cytometry (FACS), ELISA

Klon

8B9D3
  • Bindungsspezifität

    • 5
    • 2
    • 2
    • 1
    • 1
    AA 310-452

    Verwendungszweck

    IGHM Antibody

    Aufreinigung

    Purified antibody

    Immunogen

    Purified recombinant fragment of human IGHM (AA: 310-452) expressed in E. Coli.

    Isotyp

    IgG1
  • Applikationshinweise

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified antibody in PBS with 0.05 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Target

    IGHM (Immunoglobulin Heavy Constant mu (IGHM))

    Andere Bezeichnung

    IGHM

    Hintergrund

    Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD, MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).

    Molekulargewicht

    49.3 kDa

    UniProt

    P01871
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