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Desmoplakin Antikörper (pSer2849)

Der Kaninchen Polyklonal Anti-Desmoplakin-Antikörper wurde für ELISA und WB validiert. Er ist geeignet, Desmoplakin in Proben von Human zu detektieren.
Rockland
Produktnummer ABIN5596788
Hersteller Produkt- Nr.: 600-401-j65

Kurzübersicht für Desmoplakin Antikörper (pSer2849) (ABIN5596788)

Target

Alle Desmoplakin (DSP) Antikörper anzeigen
Desmoplakin (DSP)

Reaktivität

  • 38
  • 15
  • 6
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 30
  • 6
  • 2
  • 1
Kaninchen

Klonalität

  • 32
  • 7
Polyklonal

Konjugat

  • 28
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Desmoplakin Antikörper ist unkonjugiert

Applikation

  • 20
  • 15
  • 11
  • 9
  • 7
  • 6
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
ELISA, Western Blotting (WB)
  • Bindungsspezifität

    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer2849

    Hersteller Produkt- Nr.

    600-401-j65

    Hersteller

    Rockland

    Verwendungszweck

    Desmoplakin phospho S2849 Antibody

    Kreuzreaktivität (Details)

    A BLAST analysis was used to suggest cross-reactivity with mouse and human based on 100 % sequence homology.

    Produktmerkmale

    Synonyms: rabbit Anti-Desmoplakin pS2849 antibody, 250/210 kDa paraneoplastic pemphigus antigen, DP, DSP, DPI, DPII

    Aufreinigung

    Anti-Desmoplakin pS2849 was affinity purified from monospecific antiserum by immunoaffinity chromatography and is directed against the phosphorylated form of the S2849 human residue.

    Sterilität

    Sterile filtered

    Immunogen

    Immunogen: Anti-Desmoplakin pS2849 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide near the C-terminus of human Desmoplakin protein.

    Immunogen Type: Conjugated Peptide

    Isotyp

    IgG
  • Applikationshinweise

    Application Note: Anti-Desmoplakin pS2849 antibody tested in ELISA and western blot and is useful for Immunohistochemistry. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~331 kDa corresponding to the appropriate cell lysate or extract.

    Western Blot Dilution: 1 μg/mL

    ELISA Dilution: 1: 10,000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.67 mg/mL

    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: 30 % Glycerol

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

    Haltbarkeit

    12 months
  • Target

    Desmoplakin (DSP)

    Andere Bezeichnung

    DSP

    Hintergrund

    Background: Desmoplakin pS2849 is high molecular weight protein of desmosomes. It is a member of the plakin or cytolinker family and is involved in the organization of the desmosomal cadherin-plakoglobin complexes into plasma membrane domains in the anchoring of intermediate filaments to the desmosomes. The phosphorylation theoretically affects its association with epidermal, simple cytokeratins and VIM intermediate filaments. Defects in DSP are the cause of keratosis palmoplantaris striata II, Carvajal syndrome, and arrhythmogenic right ventricular cardiomyopathy 8. Anti-Desmoplakin pS2849 Antibody is ideal for researchers interested in Cell Structure research.

    UniProt

    P15924

    Pathways

    Cell-Cell Junction Organization
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