HES1 Antikörper

Produktnummer ABIN5564238

Der Maus Monoklonal Anti-HES1-Antikörper wurde für WB, ELISA und IP validiert. Er ist geeignet, HES1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für HES1 Antikörper (ABIN5564238)

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HES1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Klon: 7H11

Produktdetails anti-HES1 Antikörper

Spezifität: Recognizes human, mouse and rat HES1.

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant human Hes1 protein fused to a His-tag.

Isotyp: IgG2b

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: HEPES with 0.15M NaCl, 0.01 % BSA, 0.03 % sodium azide, and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Details zu HES1

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Andere Bezeichnung: Hairy and Enhancer of Split 1

Hintergrund: The Notch signaling pathway is important for cell-cell communication, which involve gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. It critically influences cell proliferation, differentiation, and apoptosis in metazoans. The hairy and enhancer of split (HES) family is a basic helix-loop-helix (bHLH) type trancriptional repressor and acts as Notch effectors by negatively regulating expression of downstream target genes such as tissue-specific transcription factors. HES-1 is an upstream negative regulator of REST expression. Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and beta-cells. Recent integrative genomic analyses on HES/HEY family suggest that HES1 and HES3 are target genes of the embryonic stem cell-specific network of transcription factors, and that HES1, HES5, HEY1, HEY2 and HEYL are target genes of Notch signaling pathway.

Pathways: DNA Reparatur