Rekombinanter Angiopoietin 2 Antikörper

Produktnummer ABIN5564219

Dieses Human Monoklonal-Antikörper erkennt spezifisch Angiopoietin 2 in ELISA und Func. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Rekombinanter Angiopoietin 2 Antikörper (ABIN5564219)

Target: Angiopoietin 2 (ANGPT2)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Human

Klonalität: Monoklonal

Konjugat: Dieser Angiopoietin 2 Antikörper ist unkonjugiert

Applikation: ELISA, Functional Studies (Func)

Klon: Angy-1-4

Produktdetails anti-Angiopoietin 2 Antikörper

Spezifität: Recognizes human angiopoietin-2.

Kreuzreaktivität: Human

Keine Kreuzreaktivität: Maus

Kreuzreaktivität (Details): Does not recognize mouse angiopoietin-2 and human angiopoietin-1.

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant human angiopoietin-2.

Isotyp: IgG2

Anwendungsinformationen

Kommentare:

anti-Angiopoietin-2 (human), mAb (rec.) (blocking) (Angy-1-4) is composed of human variable regions (VH and VL) (lambda-chain) of immunoglobulin fused to the human lgG2 Fc domain.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Details zu Angiopoietin 2

Target: Angiopoietin 2 (ANGPT2)

Andere Bezeichnung: Angiopoietin-2

Hintergrund: Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context. anti-Angiopoietin-2 (human), mAb (rec.) (blocking) (Angy-1-4) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.

UniProt: O15123

Pathways: RTK Signalweg