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Glycogen Synthase 1 Antikörper (pSer641)

Dieses Anti-Glycogen Synthase 1-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von Glycogen Synthase 1 in WB, IHC (p) und IF (cc). Geeignet für Human, Maus und Ratte.
Produktnummer ABIN5557475

Kurzübersicht für Glycogen Synthase 1 Antikörper (pSer641) (ABIN5557475)

Target

Alle Glycogen Synthase 1 (GYS1) Antikörper anzeigen
Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

Reaktivität

  • 62
  • 38
  • 30
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 61
  • 2
Kaninchen

Klonalität

  • 47
  • 16
Monoklonal

Konjugat

  • 42
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
Dieser Glycogen Synthase 1 Antikörper ist unkonjugiert

Applikation

  • 42
  • 28
  • 17
  • 12
  • 9
  • 8
  • 5
  • 5
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Klon

10C1
  • Bindungsspezifität

    • 17
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer641

    Kreuzreaktivität

    Human, Maus, Ratte

    Aufreinigung

    Purified by Protein A.

    Immunogen

    Synthetic peptide derived from human Glycogen synthase 1(S641), around 630-680aa (phospho S641).

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    IHC-P 1:200-400
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

    Andere Bezeichnung

    Glycogen synthase 1

    Hintergrund

    Synonyms: Glycogen synthase 1 phospho S640, Glycogen synthase 1 phospho Ser640, p-Glycogen synthase 1 S640, Glycogen synthase 1 muscle, Glycogen synthase 1, GSY, GYS, GYS1, EC 2.4.1.11, Glycogen synthase1, GYS 1, Starchsynthase muscle, UDP glucose glycogen glucosyltransferase, GYS1_HUMAN, Glycogen [starch] synthase, muscl.

    Background: Glycogen Synthase (GS) is a key enzyme in the regulation of glycogen metabolism. GS catalyzes the incorporation of UDP-glucose incorporation into glycogen. The activity of glycogen synthase is regulated by hormonal stimuli (insulin, catecholamines and glucagons) and non-hormonal stimuli (blood glucose level and exercise). Two main isoforms of mammalian GS are designated as muscle (glycogen synthase 1) and liver (glycogen synthase 2). Most tissues express glycogen synthase 1, whereas glycogen synthase 2 appears to be tissue-specific. The two isoforms have 70 % identical amino acid sequence. Glycogen synthase can be phosphorylated by multiple kinases including glycogen synthase kinase-3 (GSK-3), mitogen-activated protein kinase-related protein kinase (DYRK), and SAPK2b/p38b which leads to its inactivation.

    Gen-ID

    2997

    UniProt

    P13807

    Pathways

    PI3K-Akt Signalweg, AMPK Signaling, Cellular Glucan Metabolic Process
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