BCL2L1 Antikörper

Produktnummer ABIN5557286

Dieses Anti-BCL2L1-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von BCL2L1 in WB, IHC (p) und IF (cc). Geeignet für Human.

Kurzübersicht für BCL2L1 Antikörper (ABIN5557286)

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser BCL2L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Klon: 12C5

Produktdetails anti-BCL2L1 Antikörper

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant human Bcl-XL protein, around 1-100aa.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu BCL2L1

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Andere Bezeichnung: Bcl-XL

Hintergrund:

Synonyms: BCL2L1 phospho T47, BCL2L1 phospho Thr47, p-BCL2L1 phospho T47, p-BCL2L1 Thr47, p-BCL2L1Thr115, Apoptosis regulator Bcl X, BclX, Bcl-X, Bcl 2 like 1, Bcl 2 like 1 protein, Bcl xL, BCL X/L, BCL XL/S, Bcl xS, Bcl2 like1, BCL2-related gene, BCL2-related protein, long isoform, included, BCLXL, included, BCL2-related protein, short isoform, included, BCLXS, included, BCL2L, BCL2L1, Bclx, DKFZp781P2092, MGC113803, MGC99998, B2CL1_HUMAN.

Background: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008].

Gen-ID: 598

UniProt: Q07817

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling