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GNAS Antikörper (AA 42-188)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch GNAS in ELISA, IHC und FACS. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN5542322

Kurzübersicht für GNAS Antikörper (AA 42-188) (ABIN5542322)

Target

Alle GNAS Antikörper anzeigen
GNAS (GNAS Complex Locus (GNAS))

Reaktivität

  • 78
  • 29
  • 25
  • 10
  • 8
  • 7
  • 6
  • 5
  • 5
  • 5
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 74
  • 8
  • 1
Maus

Klonalität

  • 76
  • 7
Monoklonal

Konjugat

  • 53
  • 7
  • 6
  • 5
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser GNAS Antikörper ist unkonjugiert

Applikation

  • 66
  • 39
  • 29
  • 16
  • 12
  • 8
  • 8
  • 3
  • 3
  • 2
  • 1
  • 1
ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Klon

2A2B7
  • Bindungsspezifität

    • 10
    • 10
    • 8
    • 7
    • 7
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 42-188

    Verwendungszweck

    GNAS Antibody

    Aufreinigung

    Purified antibody

    Immunogen

    Purified recombinant fragment of human GNAS (AA: 42-188) expressed in E. Coli.

    Isotyp

    IgG2a
  • Applikationshinweise

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified antibody in PBS with 0.05 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Target

    GNAS (GNAS Complex Locus (GNAS))

    Andere Bezeichnung

    GNAS

    Hintergrund

    This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]

    Molekulargewicht

    68 kDa

    Gen-ID

    2778

    UniProt

    O95467

    Pathways

    Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Embryonic Body Morphogenesis
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