CR1L Antikörper

Produktnummer ABIN5542182

Der Ratte Monoklonal Anti-CR1L-Antikörper wurde für EIA validiert. Er ist geeignet, CR1L in Proben von Maus zu detektieren.

Kurzübersicht für CR1L Antikörper (ABIN5542182)

Target: CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CR1L Antikörper ist unkonjugiert

Applikation: Enzyme Immunoassay (EIA)

Klon: 8A-E6

Produktdetails anti-CR1L Antikörper

Spezifität: The monoclonal antibody 8A/E6 recognizes Mouse complement receptor type-1 related gene Y (Crry/p65), a type I membrane protein (MW 56-60 kDa).

Aufreinigung: Purified

Immunogen: Mouse Crry fused to Mouse IgG2a-Fc

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immuno assays.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Buffer System: PBS Preservatives: 0.02 % Sodium Azide Stabilizers: 0.1 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CR1L

Target: CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))

Andere Bezeichnung: cr1l,crry

Hintergrund: Complement comprises a system of soluble serum proteins that, upon activation by antibody (classical pathway), sugars (lectin pathway), or bacterial and foreign surfaces (alternative pathway), directly causes cell damage. Complement is constantly activated at low levels in serum, requiring cells to protect themselves from damage. In human, cells are protected from complement-mediated damage by expression of membrane-bound complement regulatory proteins, which act at serveral points along the cascade. Human cells are protected by decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and membrane attack complex inhibitor protein 1 (MIN1, CD59). Rat and mouse express a unique membrane complement regulator of the activating pathways, called complement receptor type-1 related gene Y (Crry). Crry/p65 is expressed on a wide variety of cells. Crry/p65 contains tandem short consensus repeats (SCR) characteristic of C3/C4 binding proteins. Mouse Crry/p65 has been shown to regulate both classical and alternative complement pathway C3 deposition on cell membranes. Crry/p65 must, therefore, exert its effects prior to, or at the level of, the C3 convertases, in a fashion similar to that of the human membrane factors DAF and MCP. Crry/p65 is an evolutionarily unique, complement regulatory protein which has developed in mouse and rat. Besides the involvement in control of complement damage to cell membranes Crry has also a role in T cell activation. Crry basically enhances the signals triggered by TCR/CD3 activation.

UniProt: Q64735

Pathways: Komplementsystem