MICA Antikörper

Produktnummer ABIN5542050

Der Maus Monoklonal Anti-MICA-Antikörper wurde für FACS und EIA validiert. Er ist geeignet, MICA in Proben von Human zu detektieren.

Kurzübersicht für MICA Antikörper (ABIN5542050)

Target: MICA (MHC Class I Polypeptide-Related Sequence A (MICA))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MICA Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Klon: B-Z26

Produktdetails anti-MICA Antikörper

Spezifität: This antibody recognizes both natural and recombinant MICA. Species: Human.

Aufreinigung: Ion Exchange Chromatography

Immunogen: Recombinant Human MICA

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: ELISA. Flow Cytometry: Use 10 μL to label 10 6 cells or 100 μL of whole blood.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS Preservatives: 0.09 % Sodium Azide Stabilizers: 1 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu MICA

Target: MICA (MHC Class I Polypeptide-Related Sequence A (MICA))

Andere Bezeichnung: mica

Hintergrund: The MHC class I chain-related (MIC) proteins are related to the Major histocompatibility complex (MHC) class I proteins which are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells. The MHC class I chain-related (MIC) proteins are recognized by NKG2D, a receptor on NK and T cells, and promote anti-tumor activity. MICA, a member of the MIC family, is widely expressed on many tumors, and it is the MICA/NKG2D interaction that is thought to stimulate the anti-tumor reactivity by T lymphocytes. MICA is present in virtually every tissue except the nervous system, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system. MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells.

UniProt: Q29983

Pathways: Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response