TEP1 Antikörper (N-Term)

Produktnummer ABIN5541415

Dieses Anti-TEP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TEP1 in WB und IHC (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für TEP1 Antikörper (N-Term) (ABIN5541415)

Target: TEP1 (Telomerase-Associated Protein 1 (TEP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TEP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TEP1 Antikörper

Bindungsspezifität: N-Term

Spezifität: Species: Human, Mouse and Rat.

Aufreinigung: Immunoaffinity Chromatography.

Immunogen: Synthetic Peptide corresponding to 20 Amino Acid peptide from near the amino terminus of human TP1.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Paraffin Sections (5 μg/mL). Western Blot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Phosphate Buffered Saline PBS containing 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Dilute only prior to immediate use. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu TEP1

Target: TEP1 (Telomerase-Associated Protein 1 (TEP1))

Andere Bezeichnung: tep1,tlp1

Hintergrund: Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TEP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TEP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.

UniProt: Q99973

Pathways: Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagie, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor