CD55 Antikörper

Produktnummer ABIN5541173

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD55 in WB, FACS und EIA. Er zeigt eine Reaktivität gegenüber Schwein.

Kurzübersicht für CD55 Antikörper (ABIN5541173)

Target: CD55 (Complement Decay-Accelerating Factor (CD55))

Reaktivität: Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD55 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Klon: PD2

Produktdetails anti-CD55 Antikörper

Spezifität: The monoclonal antibody PD2 recognizes Pig complement decay accelerating factor (DAF), also designated as CD55.

Aufreinigung: Purified

Immunogen: Pig DAF-Ig fusion protein.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immuno Assays. Flow Cytometry (Ref.2). Western blot. Positive Control: Porcine platelet lysate. Typical starting working dilution: 1/50.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Buffer System: PBS Stabilizers: 0.1 % BSA

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CD55

Target: CD55 (Complement Decay-Accelerating Factor (CD55))

Andere Bezeichnung: cd55,daf

Hintergrund: Cells express on their surface several proteins which protect against complement attack, namely C receptor I (CR1), decay accelerating factor (DAF), membrane cofactor protein (MCP) and CD59. CR1, DAF and MCP regulate the activation pathways of complement by either accelerating decay of the C3 and C5 convertase (CR1, DAF), or acting as cofactors for the serine protease factor I, which cleaves and irreversibly inactivates C3b (CR1, MCP). Pig DAF (CD55) is a 45-52 kDa transmembrane protein that binds C3b and C4b to inhibit formation and half-life of the C3 convertases. DAF is broadly distributed among cells in contact with serum, including both haematopoietic and nonhaematopoietic cells. Although DAF does not have an essential role in controlling hemolysis of erythrocytes, it has an important role in regulation of the deposition of C3 on nucleated cells. Together with other complement regulators DAF protects self cells from autologous complementmediated injury. DAF cooperates with CD46 in circumventing autologous C3 deposition, while CD59 inhibits the pathway at the critical end-point.

UniProt: P08174

Pathways: Komplementsystem, Regulation of Leukocyte Mediated Immunity