CD55 Antikörper (FITC)

Produktnummer ABIN5541169

Dieses Anti-CD55-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von CD55 in WB und FACS. Geeignet für Maus.

Kurzübersicht für CD55 Antikörper (FITC) (ABIN5541169)

Target: CD55 (Complement Decay-Accelerating Factor (CD55))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD55 Antikörper ist konjugiert mit FITC

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Klon: 3D5

Produktdetails anti-CD55 Antikörper (FITC)

Spezifität: The monoclonal antibody 3D5 recognizes complement decay accelerating factor (DAF), also designated as CD55.

Immunogen: NRK cells expressing transmembrane-anchored Mouse DAF

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Flow Cytometry. Western blot. The typical starting working dilution is 1/50.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8°C. This product is photosensitive and should be protected from light. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CD55

Target: CD55 (Complement Decay-Accelerating Factor (CD55))

Andere Bezeichnung: cd55,daf

Hintergrund: Cells express on their surface several proteins which protect against complement attack, namely C receptor I (CR1), decay accelerating factor (DAF), membrane cofactor protein (MCP) and CD59. CR1, DAF and MCP regulate the activation pathways of complement by either accelerating decay of the C3 and C5 convertase (CR1, DAF), or acting as cofactors for the serine protease factor I, which cleaves and irreversibly inactivates C3b (CR1, MCP). Mouse DAF (CD55) is a 60 kDa transmembrane protein that binds C3b and C4b to inhibit formation and half-life of the C3 convertases. DAF is broadly distributed among cells in contact with serum, including both haematopoietic and nonhaematopoietic cells. Although DAF does not have an essential role in controlling hemolysis of erythrocytes, it has an important role in regulation of the deposition of C3 on nucleated cells. Together with other complement regulators DAF protects self cells from autologous complementmediated injury. DAF cooperates with CD46 in circumventing autologous C3 deposition, while CD59 inhibits the pathway at the critical end-point.

UniProt: Q61475

Pathways: Komplementsystem, Regulation of Leukocyte Mediated Immunity