BCL2L1 Antikörper (pThr115)
Kurzübersicht für BCL2L1 Antikörper (pThr115) (ABIN5541071)
Target
Alle BCL2L1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- pThr115
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Sequenz
- TSQLHITpPG TAY
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Spezifität
- This antibody detects Human and other species with consensus Bcl-xL peptide (TSQLHITpPGTAY).
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Aufreinigung
- Protein G affinity
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Immunogen
- A synthetic peptide derived from Threonine 115 phosphorylated Bcl-xL, conjugated with KLH
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Applikationshinweise
- ELISA: The antibody, when 1:10,000 1:100,000 diluted, can detect the Threonine 115 phosphorylated Bcl-xL coated on ELISA plate.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Buffer
- 0.01M PBS, pH 7.4
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Konservierungsmittel
- Azide free
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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Haltbarkeit
- 12 months
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- BCL2L1 (BCL2-Like 1 (BCL2L1))
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Andere Bezeichnung
- bcl-2-like 1
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Hintergrund
- Bcl-xL is a prosurvival factor in the Bcl-2 family. It is a mitochondrial outer membrane protein that regulates the voltage-dependent anion channels (VDAC), and controls the production of reactive oxygen species and the release of cytochrome C. Bcl-xL gene knock-out resulted in embryonic lethality in animal model due to neuronal apoptosis and erythroid apoptosis. Bcl-xL is believed to be involved with the survival and differentiation of erythroid cells, iron metabolism and hemoglobin synthesis.
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Pathways
- Apoptose, Negative Regulation of intrinsic apoptotic Signaling
Target
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