CBX3 Antikörper

Produktnummer ABIN5540964

Der Maus Monoklonal anti-CBX3 Antikörper wird verwendet zum Nachweis von CBX3 in Proben von Human, Maus und Schwein. Er wurde validiert für IHC (p).

Kurzübersicht für CBX3 Antikörper (ABIN5540964)

Target: CBX3 (Chromobox Homolog 3 (CBX3))

Reaktivität: Human, Maus, Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CBX3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 2MOD-1G6

Produktdetails anti-CBX3 Antikörper

Spezifität: This antibody detects HP1γ.

Aufreinigung: Purified

Immunogen: Recombinant mouse HP1gamma

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin sections: 0.4 μg/mL (1/500). Suggested positive control: Human / Porcine brain cortex.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Buffer System: Phosphate buffered saline pH 7.2 (PBS) Preservatives: 0.01 % Kathon Stabilizers: 5 mg/mL bovine serum albumin (BSA)

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CBX3

Target: CBX3 (Chromobox Homolog 3 (CBX3))

Andere Bezeichnung: cbx3

Hintergrund: Heterochromatin Protein 1 (HP1) (Chromobox Homolog, CBX) includes three isoforms in mammals, designated α, β, and γ. HP1 proteins are approximately 25 kDa in size. They are highly conserved adapter proteins with important regulatory functi ons in the cell nucleus. These functions include notably gene silencing by heterochromatin formation. HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all Eukaryotic chromosomes. HP1β and γ also localize to euchromatic sites in the genome. Members of the HP1 family are characterized by an N-terminal chromodomain and a C-terminal chromoshadow domain, separated by a Hinge region. Chromodomain and chromoshadow domain establish secondary interactions with a large number of other proteins. HP1 proteins are subject to multiple types of post-translational modifications, including phosphorylation, acetylation, methylation, ubiquitination and sumoylation, suggesting multiple means of regulation.

UniProt: P23198