FPR2 Antikörper (2nd Extracellular Loop)

Produktnummer ABIN5540339

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FPR2 in WB, FACS, IF und ICC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für FPR2 Antikörper (2nd Extracellular Loop) (ABIN5540339)

Target: FPR2 (Formyl Peptide Receptor 2 (FPR2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FPR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-FPR2 Antikörper

Bindungsspezifität: 2nd Extracellular Loop

Sequenz: ASWGGTPEER LKC

Spezifität: This antibody recognizes a 38 kDa Human FPRL-1.

Aufreinigung: Affinity Chromatography on Protein G

Immunogen: A short peptide corresponding to the amino acids on the 2nd extracellular loop of Human FPRL1

Anwendungsinformationen

Applikationshinweise: Western blot: 1/4000-1/5000. Immunofluorescence: 1/400-1/500. Flow Cytometry: 1/100 using HL-60 as positive control .

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.01M PBS, pH 7.2

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu FPR2

Target: FPR2 (Formyl Peptide Receptor 2 (FPR2))

Andere Bezeichnung: fpr2,fprl1

Hintergrund: Human formyl peptide receptor-like 1(FPRL1) is a G-protein coupled seven transmembrane receptor. The receptor can bind to the formyl peptides derived from the degradation of the cell wall of infected bacteria and host cells. FPRL1 expressed on the cell surface of neutrophils and other leukocytes mediates the chemotaxis of these cells toward infected site. It has been reported that acute phase protein SAA is also a ligand of FPRL1 and SAA can induce the secretion of IL-8 and TNF-α by neutrophil through FPRL1 signalling. FPRL1 has also been shown to mediate the chemotaxis of microglia by Abeta42 peptide and the internalization of Abeta42 peptide into cytoplasma of macrophage, indicating that FRPL1 may participate in the Abeta42 peptide elicited pathogenesis in Alzheimer's disease.