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SIGLEC12 Antikörper (C-Term)

SIGLEC12 Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5537532
  • Target Alle SIGLEC12 Antikörper anzeigen
    SIGLEC12 (Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))
    Bindungsspezifität
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 565-595, C-Term
    Reaktivität
    • 27
    • 14
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 28
    • 3
    • 1
    Kaninchen
    Klonalität
    • 30
    • 2
    Polyklonal
    Konjugat
    • 20
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SIGLEC12 Antikörper ist unkonjugiert
    Applikation
    • 24
    • 11
    • 8
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
    Immunogen
    This SIGLEC12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 565-595 amino acids from the C-terminal region of human SIGLEC12.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product SIGLEC12 Primärantikörper
  • Applikationshinweise
    For WB starting dilution is: 1:1000

    For IHC-P starting dilution is: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    2 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    SIGLEC12 (Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))
    Andere Bezeichnung
    SIGLEC12 (SIGLEC12 Produkte)
    Synonyme
    S2V antikoerper, SIGLECL1 antikoerper, SLG antikoerper, Siglec-XII antikoerper, sialic acid binding Ig like lectin 12 (gene/pseudogene) antikoerper, sialic acid binding Ig like lectin 12 antikoerper, sialic acid binding Ig-like lectin 12 antikoerper, SIGLEC12 antikoerper
    Hintergrund
    Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. SIGLEC12 is a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. This protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor.
    Molekulargewicht
    65 kDa
    Gen-ID
    89858
    UniProt
    Q96PQ1
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