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SIGLEC5 Antikörper (C-Term)

SIGLEC5 Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5534705
  • Target Alle SIGLEC5 Antikörper anzeigen
    SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))
    Bindungsspezifität
    • 17
    • 9
    • 8
    • 7
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    AA 482-513, C-Term
    Reaktivität
    • 71
    • 28
    • 4
    Human, Maus
    Wirt
    • 63
    • 8
    • 4
    Kaninchen
    Klonalität
    • 63
    • 12
    Polyklonal
    Konjugat
    • 26
    • 12
    • 9
    • 9
    • 7
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SIGLEC5 Antikörper ist unkonjugiert
    Applikation
    • 59
    • 42
    • 21
    • 8
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This SIGLEC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-513 amino acids from the C-terminal region of human SIGLEC5.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product SIGLEC5 Primärantikörper
  • Applikationshinweise
    For WB starting dilution is: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))
    Andere Bezeichnung
    SIGLEC5 (SIGLEC5 Produkte)
    Synonyme
    CD170 antikoerper, CD33L2 antikoerper, OB-BP2 antikoerper, OBBP2 antikoerper, SIGLEC-5 antikoerper, sialic acid binding Ig like lectin 5 antikoerper, sialic acid-binding Ig-like lectin 5 antikoerper, sialic acid binding Ig-like lectin 5 antikoerper, SIGLEC5 antikoerper, LOC100597560 antikoerper, Siglec5 antikoerper
    Hintergrund
    SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIM). SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. Sequence analysis predicted that the 697-amino acid SIGLEC10 protein contains a signal peptide, an N-terminal V-set Ig-like domain and four C2-set Ig-like domains, five potential N-linked glycosylation sites, a transmembrane region, and a 126-residue cytoplasmic tail with 3 putative ITIMs. Northern blot analysis detected a major 3.0-kb SIGLEC10 transcript, with highest levels in spleen, lymph node, blood leukocytes, and appendix. Little or no expression was observed in pancreas, thyroid, and testis. Flow cytometric analysis demonstrated eosinophil-specific expression of SIGLEC10, but at a lower level than that of SIGLEC8. Expression was also detected on monocytes and a CD16-positive/CD56-negative natural killer-like lymphocyte population. After sialidase treatment, which is necessary for unmasking the sialic acid-binding site on SIGLECs interacting with cell surface sialic acids, cells expressing SIGLEC10 bound to red blood cells. Immunoprecipitation analysis indicated expression of a 100- to 120-kD monomeric protein, higher than the predicted molecular mass, suggesting that SIGLEC10 is glycosylated.
    Molekulargewicht
    61 kDa
    Gen-ID
    8778
    UniProt
    O15389
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