MCM4 Antikörper (C-Term)
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- Target Alle MCM4 Antikörper anzeigen
- MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
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Bindungsspezifität
- AA 637-665, C-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MCM4 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Aufreinigung
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This MCM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 637-665 amino acids from the C-terminal region of human MCM4.
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product MCM4 Primärantikörper
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- Applikationshinweise
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For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.5 mg/mL
- Buffer
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Target
- MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
- Andere Bezeichnung
- MCM4 (MCM4 Produkte)
- Synonyme
- cdc21 antikoerper, CDC21 antikoerper, CDC54 antikoerper, NKCD antikoerper, NKGCD antikoerper, P1-CDC21 antikoerper, hCdc21 antikoerper, 19G antikoerper, AI325074 antikoerper, AU045576 antikoerper, Cdc21 antikoerper, Mcmd4 antikoerper, mKIAA4003 antikoerper, mcdc21 antikoerper, cb1025 antikoerper, fc12c09 antikoerper, fj85g09 antikoerper, hm:zeh1616 antikoerper, wu:fc12c09 antikoerper, wu:fj85g09 antikoerper, zeh1616 antikoerper, minichromosome maintenance complex component 4 L homeolog antikoerper, minichromosome maintenance complex component 4 S homeolog antikoerper, minichromosome maintenance complex component 4 antikoerper, mcm4.L antikoerper, mcm4.S antikoerper, MCM4 antikoerper, mcm4 antikoerper, Mcm4 antikoerper
- Hintergrund
- The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
- Molekulargewicht
- 97 kDa
- Gen-ID
- 4173
- UniProt
- P33991
- Pathways
- DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
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