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KCTD11 Antikörper (AA 21-53)

KCTD11 Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5531951
  • Target Alle KCTD11 Antikörper anzeigen
    KCTD11 (Potassium Channel Tetramerisation Domain Containing 11 (KCTD11))
    Bindungsspezifität
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 21-53
    Reaktivität
    • 22
    • 19
    • 17
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 21
    • 1
    Kaninchen
    Klonalität
    • 22
    Polyklonal
    Konjugat
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser KCTD11 Antikörper ist unkonjugiert
    Applikation
    • 22
    • 13
    • 4
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This KCTD11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 21-53 amino acids from human KCTD11.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product KCTD11 Primärantikörper
  • Applikationshinweise
    For IHC-P starting dilution is: 1:25

    For WB starting dilution is: 1:1000-1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    KCTD11 (Potassium Channel Tetramerisation Domain Containing 11 (KCTD11))
    Andere Bezeichnung
    KCTD11 (KCTD11 Produkte)
    Synonyme
    KCTD11 antikoerper, AF465352 antikoerper, Ren antikoerper, C17orf36 antikoerper, KCASH1 antikoerper, REN antikoerper, REN/KCTD11 antikoerper, potassium channel tetramerization domain containing 11 antikoerper, potassium channel tetramerisation domain containing 11 antikoerper, KCTD11 antikoerper, Kctd11 antikoerper
    Hintergrund
    Plays a role as a marker and a regulator of neuronal differentiation, Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
    Molekulargewicht
    26 kDa
    Gen-ID
    147040
    UniProt
    Q693B1
    Pathways
    Hedgehog Signalweg
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