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HTRA3 Antikörper (C-Term)

HTRA3 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5518848
  • Target Alle HTRA3 Antikörper anzeigen
    HTRA3 (HtrA Serine Peptidase 3 (HTRA3))
    Bindungsspezifität
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 330-362, C-Term
    Reaktivität
    • 17
    • 4
    • 3
    • 1
    • 1
    • 1
    Human
    Wirt
    • 16
    • 1
    Kaninchen
    Klonalität
    • 16
    • 1
    Polyklonal
    Konjugat
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HTRA3 Antikörper ist unkonjugiert
    Applikation
    • 9
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Verwendungszweck
    Anti-HtrA3 Antibody Picoband®
    Sequenz
    FAIPSDRITR FLTEFQDKQI KDWKKRFIGI RMR
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Anti-HtrA3 Antibody Picoband® (ABIN5518848). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human HtrA3, different from the related mouse sequence by four amino acids, and from the related rat sequence by three amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product HTRA3 Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL, Human
    1. Nie, G.-Y., Hampton, A., Li, Y., Findlay, J. K., Salamonsen, L. A. Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2. Biochem. J. 371: 39-48, 2003.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    HTRA3 (HtrA Serine Peptidase 3 (HTRA3))
    Andere Bezeichnung
    HTRA3 (HTRA3 Produkte)
    Hintergrund

    Synonyms: Serine protease HTRA3,3.4.21.-,High-temperature requirement factor A3,Pregnancy-related serine protease,HTRA3,PRSP,

    Tissue Specificity: Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney. .

    Background: Human HtrA3 protease, which induces mitochondria-mediated apoptosis, can be a tumor suppressor and a potential therapeutic target in the treatment of cancer. It may also have a role in ovarian development, granulosa cell differentiation and luteinization. The long isoform, HTRA3L, contains 453 amino acids and has a predicted molecular mass of 49 kD. It contains an N-terminal signal peptide, followed by an insulin/IGF (see 147440)-binding domain, a Kazal-type S protease inhibitor domain, a trypsin protease domain, and a PDZ domain. The short isoform, HTRA3S, contains 357 amino acids and has a predicted molecular mass of 38 kD.

    Molekulargewicht
    49 kDa
    Gen-ID
    94031
    UniProt
    P83110
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