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HTRA3 Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HTRA3 in WB. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN5518848

Kurzübersicht für HTRA3 Antikörper (C-Term) (ABIN5518848)

Target

Alle HTRA3 Antikörper anzeigen
HTRA3 (HtrA Serine Peptidase 3 (HTRA3))

Reaktivität

  • 19
  • 5
  • 3
  • 2
  • 1
  • 1
  • 1
Human

Wirt

  • 18
  • 1
Kaninchen

Klonalität

  • 18
  • 1
Polyklonal

Konjugat

  • 12
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser HTRA3 Antikörper ist unkonjugiert

Applikation

  • 11
  • 3
  • 2
  • 2
Western Blotting (WB)
  • Bindungsspezifität

    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 330-362, C-Term

    Verwendungszweck

    Anti-HtrA3 Antibody Picoband®

    Sequenz

    FAIPSDRITR FLTEFQDKQI KDWKKRFIGI RMR

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-HtrA3 Antibody Picoband® (ABIN5518848). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of human HtrA3, different from the related mouse sequence by four amino acids, and from the related rat sequence by three amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human
    1. Nie, G.-Y., Hampton, A., Li, Y., Findlay, J. K., Salamonsen, L. A. Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2. Biochem. J. 371: 39-48, 2003.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    HTRA3 (HtrA Serine Peptidase 3 (HTRA3))

    Andere Bezeichnung

    HTRA3

    Hintergrund

    Synonyms: Serine protease HTRA3,3.4.21.-,High-temperature requirement factor A3,Pregnancy-related serine protease,HTRA3,PRSP,

    Tissue Specificity: Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney. .

    Background: Human HtrA3 protease, which induces mitochondria-mediated apoptosis, can be a tumor suppressor and a potential therapeutic target in the treatment of cancer. It may also have a role in ovarian development, granulosa cell differentiation and luteinization. The long isoform, HTRA3L, contains 453 amino acids and has a predicted molecular mass of 49 kD. It contains an N-terminal signal peptide, followed by an insulin/IGF (see 147440)-binding domain, a Kazal-type S protease inhibitor domain, a trypsin protease domain, and a PDZ domain. The short isoform, HTRA3S, contains 357 amino acids and has a predicted molecular mass of 38 kD.

    Molekulargewicht

    49 kDa

    Gen-ID

    94031

    UniProt

    P83110
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