HTRA3 Antikörper (C-Term)

Produktnummer ABIN5518848

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HTRA3 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für HTRA3 Antikörper (C-Term) (ABIN5518848)

Target: HTRA3 (HtrA Serine Peptidase 3 (HTRA3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HTRA3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HTRA3 Antikörper

Bindungsspezifität: AA 330-362, C-Term

Verwendungszweck: Anti-HtrA3 Antibody Picoband®

Sequenz: FAIPSDRITR FLTEFQDKQI KDWKKRFIGI RMR

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-HtrA3 Antibody Picoband® (ABIN5518848). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human HtrA3, different from the related mouse sequence by four amino acids, and from the related rat sequence by three amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human
1. Nie, G.-Y., Hampton, A., Li, Y., Findlay, J. K., Salamonsen, L. A. Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2. Biochem. J. 371: 39-48, 2003.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu HTRA3

Target: HTRA3 (HtrA Serine Peptidase 3 (HTRA3))

Andere Bezeichnung: HTRA3

Hintergrund:

Synonyms: Serine protease HTRA3,3.4.21.-,High-temperature requirement factor A3,Pregnancy-related serine protease,HTRA3,PRSP,

Tissue Specificity: Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney. .

Background: Human HtrA3 protease, which induces mitochondria-mediated apoptosis, can be a tumor suppressor and a potential therapeutic target in the treatment of cancer. It may also have a role in ovarian development, granulosa cell differentiation and luteinization. The long isoform, HTRA3L, contains 453 amino acids and has a predicted molecular mass of 49 kD. It contains an N-terminal signal peptide, followed by an insulin/IGF (see 147440)-binding domain, a Kazal-type S protease inhibitor domain, a trypsin protease domain, and a PDZ domain. The short isoform, HTRA3S, contains 357 amino acids and has a predicted molecular mass of 38 kD.

Molekulargewicht: 49 kDa

Gen-ID: 94031

UniProt: P83110