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alpha Defensin 1 Antikörper (C-Term)

Dieses Anti-alpha Defensin 1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von alpha Defensin 1 in WB. Geeignet für Human und Ratte.
Produktnummer ABIN5518754

Kurzübersicht für alpha Defensin 1 Antikörper (C-Term) (ABIN5518754)

Target

Alle alpha Defensin 1 (DEFA1) Antikörper anzeigen
alpha Defensin 1 (DEFA1) (Defensin, alpha 1 (DEFA1))

Reaktivität

  • 33
  • 5
  • 2
Human, Ratte

Wirt

  • 21
  • 11
  • 4
Kaninchen

Klonalität

  • 32
  • 4
Polyklonal

Konjugat

  • 21
  • 5
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser alpha Defensin 1 Antikörper ist unkonjugiert

Applikation

  • 23
  • 16
  • 13
  • 6
  • 6
  • 6
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 65-94, C-Term

    Verwendungszweck

    Anti-Alpha Defensin 1/DEFA1 Antibody Picoband®

    Sequenz

    ACYCRIPACI AGERRYGTCI YQGRLWAFCC

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-Alpha Defensin 1/DEFA1 Antibody Picoband® (ABIN5518754). Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of human Alpha Defensin 1.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human, Rat
    1. "Entrez Gene: DEFA1 defensin, alpha 1". 2. Aldred PM, Hollox EJ, Armour JA (Jul 2005). "Copy number polymorphism and expression level variation of the human alpha-defensin genes DEFA1 and DEFA3".Hum Mol Genet. 14 (14): 2045-52. 3. Feng Y, Gutekunst CA, Eberhart DE, Yi H, Warren ST, Hersch SM (Mar 1997). "Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes". J Neurosci. 17 (5): 1539-47.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    alpha Defensin 1 (DEFA1) (Defensin, alpha 1 (DEFA1))

    Andere Bezeichnung

    DEFA1

    Hintergrund

    Synonyms: Neutrophil defensin 1,Defensin, alpha 1,HNP-1,HP-1,HP1,HP 1-56,Neutrophil defensin 2,HNP-2,HP-2,HP2,DEFA1,DEF1, DEFA2, MRS,DEFA1B,

    Tissue Specificity: Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

    Background: Defensin, alpha 1, also known as human alpha defensin 1, human neutrophil peptide 1 (HNP-1) or neutrophil defensin 1 is a human protein that is encoded by the DEFA1 gene. Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.

    Molekulargewicht

    19 kDa

    Gen-ID

    1667

    UniProt

    P59665

    Pathways

    Cellular Response to Molecule of Bacterial Origin
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