WDR48 Antikörper (C-Term)

Produktnummer ABIN5517644

Der Kaninchen Polyklonal anti-WDR48 Antikörper (ABIN5517644) detektiert spezifisch WDR48 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für WDR48 Antikörper (C-Term) (ABIN5517644)

Target: WDR48 (WD Repeat Domain 48 (WDR48))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WDR48 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-WDR48 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: WDR48 Antibody - C-terminal region

Sequenz: YEKIINLDNE SQTTSSSNNE KPGEQEKEED IAVLAEEKIE LLCQDQVLDP

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human WDR48

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP75711-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu WDR48

Target: WDR48 (WD Repeat Domain 48 (WDR48))

Andere Bezeichnung: WDR48

Hintergrund:

Background Information: Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029). Enhances the USP1-mediated deubiquitination of FANCD2, USP1 being almost inactive by itself (PubMed:18082604). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.

Gene Name: WD repeat domain 48

Alternative Symbols: P80, UAF1, Bun62, SPG60

Protein Name: WD repeat-containing protein 48

Molekulargewicht: 74 kDa

Gen-ID: 57599

NCBI Accession: NP_065890

UniProt: Q8TAF3