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WDR48 Antikörper (C-Term)

WDR48 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5517644
  • Target Alle WDR48 Antikörper anzeigen
    WDR48 (WD Repeat Domain 48 (WDR48))
    Bindungsspezifität
    • 10
    • 10
    • 7
    • 1
    C-Term
    Reaktivität
    • 20
    • 4
    • 3
    Human
    Wirt
    • 21
    Kaninchen
    Klonalität
    • 21
    Polyklonal
    Konjugat
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser WDR48 Antikörper ist unkonjugiert
    Applikation
    • 19
    • 17
    • 15
    • 13
    • 4
    • 1
    Western Blotting (WB)
    Sequenz
    YEKIINLDNE SQTTSSSNNE KPGEQEKEED IAVLAEEKIE LLCQDQVLDP
    Aufreinigung
    Affinity purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human WDR48
    Top Product
    Discover our top product WDR48 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    WDR48 (WD Repeat Domain 48 (WDR48))
    Andere Bezeichnung
    WDR48 (WDR48 Produkte)
    Synonyme
    P80 antikoerper, UAF1 antikoerper, 8430408H12Rik antikoerper, mKIAA1449 antikoerper, WD repeat domain 48 antikoerper, WDR48 antikoerper, Wdr48 antikoerper
    Hintergrund
    Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029). Enhances the USP1-mediated deubiquitination of FANCD2, USP1 being almost inactive by itself (PubMed:18082604). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.

    Alias Symbols: P80, UAF1, SPG60

    Protein Size: 677
    Gen-ID
    57599
    NCBI Accession
    NM_001303402, NP_065890
    UniProt
    Q8TAF3
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