UBXN1 Antikörper (N-Term)

Produktnummer ABIN5517553

Der Kaninchen Polyklonal Anti-UBXN1-Antikörper wurde für WB validiert. Er ist geeignet, UBXN1 in Proben von Human zu detektieren.

Kurzübersicht für UBXN1 Antikörper (N-Term) (ABIN5517553)

Target: UBXN1 (UBX Domain Protein 1 (UBXN1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBXN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-UBXN1 Antikörper

Bindungsspezifität: N-Term

Sequenz: GRAEKALALT GNQGIEAAMD WLMEHEDDPD VDEPLETPLG HILGREPTSS

Produktmerkmale: This is a rabbit polyclonal antibody against UBXN1. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human UBXN1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu UBXN1

Target: UBXN1 (UBX Domain Protein 1 (UBXN1))

Andere Bezeichnung: UBXN1

Hintergrund: UBXN1 is a ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. It specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1,it leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. It is a component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.

Alias Symbols: UBXN1, SAKS1,

Protein Interaction Partner: UBXN1, UBQLN1, FAM189A2, PLAA, TRIM39, VCP, UBE2I, UBC, PLA2G4A, MAVS, NSFL1C, STK26, TRNT1, MCTS1, TWF2, PROSC, BASP1, DENR, YWHAE, TXNRD1, TUFM, TUBB2A, PAFAH1B1, HSPA5, HMGB3, HK1, CTPS1, CAPN2, CD81, CSE1L, CLNS1A, ATP6V1A, SSSCA1, USP34, SEC22B, VPS4

Protein Size: 297

Gen-ID: 51035

UniProt: Q04323