UBXN1 Antikörper (C-Term)

Produktnummer ABIN5517552

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch UBXN1 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für UBXN1 Antikörper (C-Term) (ABIN5517552)

Target: UBXN1 (UBX Domain Protein 1 (UBXN1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBXN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-UBXN1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: UBXN1 Antibody - C-terminal

Sequenz: RAKKYGGSVG SQPPPVAPEP GPVPSSPSQE PPTKREYDQC RIQVRLPDGT

Produktmerkmale: This is a rabbit polyclonal antibody against UBXN1. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human UBXN1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP75559-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu UBXN1

Target: UBXN1 (UBX Domain Protein 1 (UBXN1))

Andere Bezeichnung: UBXN1

Hintergrund:

Background Information: UBXN1 is a ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. It specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, it leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. It is a component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.

Alternative Symbols: 2B28, SAKS1, UBXD10

Molekulargewicht: 32 kDa

Gen-ID: 51035

UniProt: Q04323