SETD7 Antikörper (N-Term)

Produktnummer ABIN5517321

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SETD7 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Hund, Pferd, Schwein, Kaninchen, Rind (Kuh), Zebrafisch (Danio rerio) und Meerschweinchen.

Kurzübersicht für SETD7 Antikörper (N-Term) (ABIN5517321)

Target: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Schwein, Kaninchen, Rind (Kuh), Zebrafisch (Danio rerio), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SETD7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SETD7 Antikörper

Bindungsspezifität: N-Term

Sequenz: MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against SETD7. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SETD7

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SETD7

Target: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Andere Bezeichnung: SETD7

Hintergrund: SETD7 is a histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Alias Symbols: SETD7, KIAA1717, KMT7, SET7, SET9,

Protein Interaction Partner: KLF4, HIST3H3, SOX2, PRKAR1A, A1BG, TP53, NR2F2, STEAP3, SERTAD1, DPY30, MED1, MYOD1, E2F1, HIST1H3A, SMARCA4, H3F3A, STAT3, RELA, AR, UBC, DNMT1, PPP1R12A, SIRT1, TBP, TAF10, TAF7, TAF6, HIST1H4A, ESR1, HIST2H3C, HCFC1, L3MBTL1,

Protein Size: 366

Gen-ID: 80854

NCBI Accession: NP_085151

UniProt: Q8WTS6