Spindlin 1 Antikörper (N-Term)

Produktnummer ABIN5516939

Dieses Anti-Spindlin 1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Spindlin 1 in WB. Geeignet für Human, Maus, Ratte, Schwein, Rind (Kuh), Hund und Kaninchen.

Kurzübersicht für Spindlin 1 Antikörper (N-Term) (ABIN5516939)

Target: Spindlin 1 (SPIN1)

Reaktivität: Human, Maus, Ratte, Schwein, Rind (Kuh), Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Spindlin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Spindlin 1 Antikörper

Bindungsspezifität: N-Term

Sequenz: KTPFGKTPGQ RSRADAGHAG VSANMMKKRT SHKKHRSSVG PSKPVSQPRR

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SPIN1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SPIN1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Spindlin 1

Target: Spindlin 1 (SPIN1)

Andere Bezeichnung: SPIN1

Hintergrund: SPIN1 is a chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006).It may play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

Alias Symbols: SPIN1, OCR, SPIN,

Protein Interaction Partner: SUMO2, UBC, PRMT6, BAG3, NPM1, UBL4A, SMURF1, EIF4A3, YWHAE, MAGOH, GRK5, TCF3, ARRB2, ARRB1, ELAVL1, AGO3, PTN,

Protein Size: 262

Gen-ID: 10927

NCBI Accession: NP_006708

UniProt: Q9Y657