NLRP12 Antikörper (N-Term)

Produktnummer ABIN5516341

Der Kaninchen Polyklonal anti-NLRP12 Antikörper wird verwendet zum Nachweis von NLRP12 in Proben von Human, Maus, Ratte, Rind (Kuh), Schwein und Hund. Er wurde validiert für WB.

Kurzübersicht für NLRP12 Antikörper (N-Term) (ABIN5516341)

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRP12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NLRP12 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: NLRP12 Antibody - N-terminal region

Sequenz: LEVSLVTPRK DPQETYRDYV RRKFRLMEDR NARLGECVNL SHRYTRLLLV

Homologie: Cow: 100%, Dog: 90%, Human: 100%, Mouse: 77%, Pig: 100%, Rat: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against NLRP12. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human NLRP12

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64968-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu NLRP12

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Andere Bezeichnung: NLRP12

Hintergrund:

Background Information: This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants.

Gene Name: NLR family, pyrin domain containing 12

Alternative Symbols: RNO, PAN6, RNO2, FCAS2, NALP12, PYPAF7, CLR19.3

Protein Name: NACHT, LRR and PYD domains-containing protein 12

Molekulargewicht: 116kDa

Gen-ID: 91662

NCBI Accession: NP_653288

UniProt: P59046

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome