NANOS2 Antikörper (C-Term)

Produktnummer ABIN5514981

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NANOS2 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Hund, Ziege, Meerschweinchen, Pferd, Schwein und Kaninchen.

Kurzübersicht für NANOS2 Antikörper (C-Term) (ABIN5514981)

Target: NANOS2 (Nanos Homolog 2 (NANOS2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Ziege, Meerschweinchen, Pferd, Schwein, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NANOS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NANOS2 Antikörper

Bindungsspezifität: C-Term

Sequenz: TPDGVVVCPI LRHYVCPVCG ATGDQAHTLK YCPLNGGQQS LYRRSGRNSA

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against NANOS2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human NANOS2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NANOS2

Target: NANOS2 (Nanos Homolog 2 (NANOS2))

Andere Bezeichnung: NANOS2

Hintergrund: NANOS2 plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. It represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. It maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. It regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. It is required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state.

Alias Symbols: NANOS2, NOS2,

Protein Interaction Partner: CCNDBP1, MAGEA12,

Protein Size: 138

Gen-ID: 339345

NCBI Accession: NP_001025032

UniProt: P60321

Pathways: Retinoic Acid Receptor Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance