Complement Factor I Antikörper (C-Term)

Produktnummer ABIN5514688

Der Kaninchen Polyklonal Anti-Complement Factor I-Antikörper wurde für WB validiert. Er ist geeignet, Complement Factor I in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Schwein und Kaninchen zu detektieren.

Kurzübersicht für Complement Factor I Antikörper (C-Term) (ABIN5514688)

Target: Complement Factor I (CFI)

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Schwein, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Complement Factor I Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Complement Factor I Antikörper

Bindungsspezifität: C-Term

Sequenz: AGTYDGSIDA CKGDSGGPLV CMDANNVTYV WGVVSWGENC GKPEFPGVYT

Homologie: Cow: 77%, Dog: 77%, Guinea Pig: 79%, Horse: 83%, Human: 100%, Mouse: 86%, Pig: 85%, Rabbit: 83%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against CFI. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CFI

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Complement Factor I

Target: Complement Factor I (CFI)

Andere Bezeichnung: CFI

Hintergrund: This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.

Alias Symbols: CFI, IF,

Protein Interaction Partner: GLP1R, CFH, C3,

Protein Size: 583

Gen-ID: 3426

NCBI Accession: NM_000204, NP_000195

UniProt: P05156

Pathways: Komplementsystem