CD86 Antikörper

Produktnummer ABIN5067873

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD86 in FACS. Er zeigt eine Reaktivität gegenüber Human, Cynomolgus, Pavian und Rhesusaffen.

Kurzübersicht für CD86 Antikörper (ABIN5067873)

Target: CD86

Reaktivität: Human, Cynomolgus, Pavian, Rhesusaffen

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD86 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Güteklasse: GMP Grade

Klon: BU63

Produktdetails anti-CD86 Antikörper

Verwendungszweck: CD86 Unconjugated Antibody

Produktmerkmale: BU63 recognizes ~70Kda a surface antigen protein of Ig superfamily characterized as CD86 expressed by most antigen presenting cells (APC). Depending on the immunological condition, CD86 specifically binds with its two ligands CD28 and CD152 (CTLA-4) expressed by T cells. Binding with CD28, CD86 provides stimulatory signal and activates T cells whereas binding with CD152 (CTLA-4) CD86 provides inhibitory signal to T cells. Generally, high-level CD86 expression was noticed on peripheral monocytes, tissue macrophages and dendritic cells, and also on activated B cells. CD86 is useful in the clinical diagnosis of cancer cells including malignant Hodgkin's and non-hodgkin's diseases.

Aufreinigung: Purified

Reinheit: >95 %

Immunogen: B-lymphoblastoid cell line ARH 77

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS pH 7.2, 0.1 % (w/v) BSA, 0.09 % (w/v) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu CD86

Target: CD86

Andere Bezeichnung: CD86

UniProt: P42081

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation