NBN
Reaktivität: Human
WB, ELISA
Wirt: Maus
Monoclonal
3E4
unconjugated
Applikationshinweise
Optimal working dilutions should be determined experimentally by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Lagerung
-20 °C
Target
Nibrin (NBN)
Andere Bezeichnung
p95/NBS1
Hintergrund
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.