Nibrin Antikörper (AA 350-400)
Kurzübersicht für Nibrin Antikörper (AA 350-400) (ABIN504727)
Target
Alle Nibrin (NBN) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 350-400
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Kreuzreaktivität
- Human, Maus
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Aufreinigung
- affinity purified
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Immunogen
- Synthetic peptide made to an internal portion of the mouse protein (within AA 350-400). [Swiss-Prot# Q9R207].
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Isotyp
- IgG
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Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Lagerung
- -20 °C
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- Nibrin (NBN)
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Andere Bezeichnung
- p95/NBS1
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Hintergrund
- The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
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UniProt
- Q9R207
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Pathways
- DNA Reparatur, Production of Molecular Mediator of Immune Response
Target
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