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VAV2 Antikörper (AA 610-824)

VAV2 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5027629
  • Target Alle VAV2 Antikörper anzeigen
    VAV2 (Vav 2 Guanine Nucleotide Exchange Factor (VAV2))
    Bindungsspezifität
    • 15
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 610-824
    Reaktivität
    • 48
    • 16
    • 10
    Human
    Wirt
    • 41
    • 5
    • 1
    • 1
    Kaninchen
    Klonalität
    • 36
    • 12
    Polyklonal
    Konjugat
    • 27
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser VAV2 Antikörper ist unkonjugiert
    Applikation
    • 38
    • 14
    • 13
    • 13
    • 13
    • 11
    • 9
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Aufreinigung
    Protein A Chromatography
    Immunogen
    A partial length recombinant VAV2 protein (amino acids 610-824) was used as the immunogen for this antibody.
    Isotyp
    IgG
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  • Applikationshinweise
    WB: 1-2 μg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    PBS containing 0.05 % BSA, PH 7.4
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
  • Target
    VAV2 (Vav 2 Guanine Nucleotide Exchange Factor (VAV2))
    Andere Bezeichnung
    VAV2 (VAV2 Produkte)
    Synonyme
    VAV-2 antikoerper, 2810040F13Rik antikoerper, AI847175 antikoerper, vav guanine nucleotide exchange factor 2 antikoerper, vav 2 oncogene antikoerper, VAV2 antikoerper, Vav2 antikoerper
    Hintergrund
    Vav2 is a member of the Vav family that serves as a GRF (guanine nucleotide exchange factor) for the Rho family of Ras-related GTPases. It is widely expressed and regulates processes including cell migration, neuronal development and phagocytosis through interactions with different proteins. Vav2, a GEF for Rac1, RhoA, and Cdc42, is shown to be regulated by a phosphorylation-dependent interaction with PKL (Paxillin kinase linker). PKL is required for Vav2 activation downstream of integrin engagement and epidermal growth factor (EGF) stimulation. During the process of spinal neurons, the Vav2 activity is necessary for optimal neurite outgrowth and promotes branching by targeting GEF activity to branch points.
    Molekulargewicht
    90 kDa
    Gen-ID
    7410
    UniProt
    P52735
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung
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