Vangl1 Antikörper (AA 148-400)

Produktnummer ABIN5027627

Dieses Anti-Vangl1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Vangl1 in WB. Geeignet für Human.

Kurzübersicht für Vangl1 Antikörper (AA 148-400) (ABIN5027627)

Target: Vangl1 (Vang-Like 1 (Vangl1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Vangl1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Vangl1 Antikörper

Bindungsspezifität: AA 148-400

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant Vang like-1 protein (amino acids 148-400) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu Vangl1

Target: Vangl1 (Vang-Like 1 (Vangl1))

Andere Bezeichnung: Vang like-1

Hintergrund: Vangl1 (VANGL planar cell polarity protein 1) is an integral membrane protein that belongs to the tetraspanin family having four transmembrane domains. Tetraspanins form large multimolecular complexes on the cell membrane and are involved in cellular signaling, membrane formation, and migration. Vangl1 is expressed at the plasma membrane of different tissues and play a critical role in establishing planar cell polarity (PCP) in epithelial cells and are required for convergent extension (CE) movements during embryogenesis. It is a highly conserved and have evolved from a single ancestral protein Strabismus/Van Gogh found in Drosophila. Mutations in the vangl1 gene cause NTDs (neural tube defects). Ser/Thr phosphorylation of Vangl1 serves as an effector mediating the ITF healing response of the intestinal mucosa. In colon carcinoma cell lines, Vangl1 interacts with KAI1 (CD82) tumor metastasis suppressor. Vangl1 overexpression increases motility and metastasis, whereas its inhibition decreases motility and metastasis of colon cancer confirming migratory phenotype for Vangl1 in colonic epithelial cells.

Molekulargewicht: 62 kDa

Gen-ID: 81839

UniProt: Q8TAA9

Pathways: WNT Signalweg