CRLF2 Antikörper (AA 97-252)

Produktnummer ABIN5027607

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CRLF2 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CRLF2 Antikörper (AA 97-252) (ABIN5027607)

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CRLF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: ABM2D87

Produktdetails anti-CRLF2 Antikörper

Bindungsspezifität: AA 97-252

Aufreinigung: Protein G Chromatography

Immunogen: A partial length recombinant TSLPR protein (amino acids 97-252) was used as the immunogen for this antibody.

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu CRLF2

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Andere Bezeichnung: TSLP Receptor

Hintergrund: TSLPR (thymic stromal lymphopoietin receptor) also known as CRLF2 (cytokine receptor-like factor 2) is a member of type I cytokine receptor. It binds its ligand TSLP (thymic stromal lymphopoietin) as a heterodimer with IL7R. TSLP ligand is produced by epithelial cells in order to activate dendritic cells, and is involved in inflammation, allergic responses as well as B-cell precursor proliferation and survival. The interaction between TSLP and its heterodimeric receptor activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. High expression of CRLF2 is associated with a poor prognosis in adult and high-risk pediatric cases of B-ALL (B-cell acute lymphoblastic leukemias).

Molekulargewicht: 42 kDa

Gen-ID: 64109

UniProt: Q9HC73