SPARC Antikörper (AA 52-268)

Produktnummer ABIN5027541

Produktdetails anti-SPARC Antikörper

Target: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Bindungsspezifität: AA 52-268

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPARC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant SPARC/Osteonectin protein (amino acids 52-268) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu SPARC

Target: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Andere Bezeichnung: SPARC/Osteonectin (SPARC Produkte)

Synonyme: ON antikoerper, AA517111 antikoerper, BM-40 antikoerper, hm:zeh0062 antikoerper, SPARC antikoerper, sparc antikoerper, secreted protein acidic and cysteine rich antikoerper, secreted acidic cysteine rich glycoprotein antikoerper, secreted protein, acidic, cysteine-rich (osteonectin) antikoerper, secreted protein, acidic, cysteine-rich (osteonectin) L homeolog antikoerper, secreted protein, acidic, cysteine-rich (osteonectin) S homeolog antikoerper, SPARC antikoerper, Sparc antikoerper, sparc antikoerper, sparc.L antikoerper, sparc.S antikoerper

Hintergrund: SPARC (Secreted protein, acidic, cysteine-rich) is a glycoprotein that binds to collagen type I and other proteins in the extracellular matrix. It is involved in normal tissue remodeling as it regulates the deposition of extracellular matrix, and also plays a role in neoplastic transformation. It modulates interactions between tumoral cells and the peri-tumoral stroma. Homozygous mutations in SPARC give rise to severe bone fragility in humans. SPARC negatively regulates glucose metabolism in hepatocellular carcinoma (HCC). Overexpression of SPARC inhibited glucose uptake and lactate product through downregulation of key enzymes of glucose metabolism.

Molekulargewicht: 35 kDa

Gen-ID: 6678

UniProt: P09486

Pathways: Autophagie