Bax Inhibitor 1 Antikörper (AA 1-200)

Produktnummer ABIN5027485

Der Maus Monoklonal anti-Bax Inhibitor 1 Antikörper wird verwendet zum Nachweis von Bax Inhibitor 1 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für Bax Inhibitor 1 Antikörper (AA 1-200) (ABIN5027485)

Target: Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Bax Inhibitor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: ABM20E4

Produktdetails anti-Bax Inhibitor 1 Antikörper

Bindungsspezifität: AA 1-200

Aufreinigung: Protein G Chromatography

Immunogen: A partial length recombinant protein of human Bi-1 (amino acids 1-200) was used as an immunogen for this antibody.

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: WB: 4-6 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu Bax Inhibitor 1

Target: Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))

Andere Bezeichnung: Bi-1

Hintergrund: Bi-1 is an anti-apoptotic protein that inhibits Bax activation and its translocation to the mitochondria. Functionally, BI-1 affects the leakage of Ca2+ ions from the ER. In addition to its anti-apoptotic role, BI-1 also enhances cancer/tumor progression. It belongs to the Bcl-2 family, plays an important role in the mitochondrial apoptosis pathway. Bi-1 over-expression suppresses apoptosis induced by Bax, staurosporine and growth factor deprivation. BI-1 is presumably not needed for the physiological regulation of developmental programmed cell death. The anti-apoptotic mechanism of BI-1 involves the suppression of Bax activation and translocation to mitochondria, preserving the mitochondria membrane potential and mitochondrial morphology, and preventing the activation of post-mitochondrial caspases. BI-1 function is also associated with the regulation of intracellular Ca2+ omeostasis. In several human cancers, including nasopharyngeal carcinoma, its expression was found to be increased, however, up-regulated expression of this protein has been linked to increased cell proliferations.

Molekulargewicht: 30 kDa

Gen-ID: 7009

UniProt: P55061

Pathways: Response to Water Deprivation, ER-Nucleus Signaling