DNMT3A Antikörper

Produktnummer ABIN5027477

Produktdetails anti-DNMT3A Antikörper

Target: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DNMT3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Aufreinigung: Protein G Chromatography

Immunogen: A partial length recombinant protein from DNMT3a was used as the immunogen for this antibody.

Klon: ABM13G4

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL, FACS: 0.5-1 μg/10^6

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu DNMT3A

Target: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Andere Bezeichnung: DNMT3a (DNMT3A Produkte)

Synonyme: DNMT3A antikoerper, DNMT3A2 antikoerper, M.HsaIIIA antikoerper, MmuIIIA antikoerper, dnmt3a1 antikoerper, dnmt6 antikoerper, DNA methyltransferase 3 alpha antikoerper, DNA methyltransferase 3A antikoerper, DNA (cytosine-5-)-methyltransferase 3 alpha b antikoerper, DNMT3A antikoerper, Dnmt3a antikoerper, dnmt3a antikoerper, dnmt3ab antikoerper

Hintergrund: Dnmt3a belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. Dnmt3a together with other methyltransferases conducts de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring. Dnmt3a also directs a metabolic program by repressing key genes to enable the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been found in several cancers including AML (Acute Myeloid Leukemia).

Molekulargewicht: 15.99

Gen-ID: 1788

UniProt: Q9Y6K1