DNMT3A Antikörper (C-Term)

Produktnummer ABIN387865

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch DNMT3A in WB. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für DNMT3A Antikörper (C-Term) (ABIN387865)

Target: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNMT3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB12504

Produktdetails anti-DNMT3A Antikörper

Bindungsspezifität: AA 723-752, C-Term

Homologie: M, Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Dnmt3A/Dnmt3A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723-752 amino acids from the C-terminal region of human Dnmt3A/Dnmt3A2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-DNMT3A Antikörper (ABIN387865)

ODoherty, OShea, Sandra, Lonergan, Fair, Forde: "Imprinted and DNA methyltransferase gene expression in the endometrium during the pre- and peri-implantation period in cattle." in: Reproduction, fertility, and development, Vol. 29, Issue 9, pp. 1729-1738, (2018) (PubMed).

ODoherty, OShea, Fair: "Bovine DNA methylation imprints are established in an oocyte size-specific manner, which are coordinated with the expression of the DNMT3 family proteins." in: Biology of reproduction, Vol. 86, Issue 3, pp. 67, (2012) (PubMed).

Details zu DNMT3A

Target: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Andere Bezeichnung: Dnmt3A/Dnmt3A2

Hintergrund: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. DNMT3A is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.

Molekulargewicht: 101858

Gen-ID: 1788

NCBI Accession: NP_072046, NP_715640, NP_783328, NP_783329

UniProt: Q9Y6K1