NLRP2 Antikörper (AA 850-1060)

Produktnummer ABIN5027382

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NLRP2 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für NLRP2 Antikörper (AA 850-1060) (ABIN5027382)

Target: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NLRP2 Antikörper

Bindungsspezifität: AA 850-1060

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant NALP2 protein (amino acids 850-1060) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu NLRP2

Target: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Andere Bezeichnung: NALP2

Hintergrund: NALP2 (also known as PAN1/PYPAF2) is a member of the NLR (NACHT-LRR) family which includes both NODs and NALPs. Alternative names for the NLR family include CATERPILLER, NOD and NOD-LRR. NLR family members are thought to be intracellular pathogen-recognition receptors (PRRs). At least fourteen NALPs have been identified in the human genome, and a common feature among NALPs 1-3, 6, and 12 is their ability to recruit the adaptor protein ASC through a homotypic PYD-PYD interaction, which in turn recruits caspase-1 through a CARD-CARD interaction. The oligomerization of NALPs is thought to bring the inflammatory caspases into close proximity leading to their activation within the inflammasome. The NALP2/3 inflammasomes contain, in addition to NALP2 or NALP3, the caspase recruitment domain (CARD)-containing protein Cardinal, ASC and caspase 1. Processing of the pro-inflammatory cytokines IL-1b and IL-18 by caspases leads to to the secretion of active cytokines and elicits a potent inflammatory response. The expression of NALP2 is upregulated in THP-1 macrophage cells by LPS and certain cytokines including interferon g and b, supporting a role for NALP2 in host-defense and inflammation. Additionally, NALP2 is expressed in several human tumor cell lines. However, the endogenous expression of NALP2 varies widely among tumor cells lines, with the highest levels found in MCF-7 and MDA-MB-435 breast cancer, Caco2 colon cancer and UACC62 melanoma cells. This antibody recognizes NALP2, human NALP2 is a 1062 amino acid protein, it is specific for NALP2 does not cross-react with related family members PAN2 or NAC.

Molekulargewicht: 115 kDa

Gen-ID: 55655

UniProt: Q9NX02

Pathways: Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome