MUM1 Antikörper (AA 52-278)

Produktnummer ABIN5027376

Produktdetails anti-MUM1 Antikörper

Target: MUM1 (Melanoma Associated Antigen (Mutated) 1 (MUM1))

Bindungsspezifität: AA 52-278

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MUM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant MUM1 protein (amino acids 52-278) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1-2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu MUM1

Target: MUM1 (Melanoma Associated Antigen (Mutated) 1 (MUM1))

Andere Bezeichnung: MUM1 (MUM1 Produkte)

Synonyme: EXPAND1 antikoerper, HSPC211 antikoerper, MUM-1 antikoerper, IRF4 antikoerper, 2610019J09 antikoerper, 9430059D04Rik antikoerper, UBE-1C2 antikoerper, melanoma associated antigen (mutated) 1 antikoerper, PWWP domain-containing protein MUM1 antikoerper, MUM1 antikoerper, LOC612320 antikoerper, Mum1 antikoerper

Hintergrund: MUM1 is a member of the interferon regulatory factor family of transcription factors. This protein is required at several stages of B-cell development, including in the differentiation of mature B cell into antibody-secreting plasma cells, and is also critical for Th2 and Th17 T-cell differentiation and T-cell cytotoxic function. MUM1 is normally expressed in plasma cells, melanocytes, some B cells, and activated T cells. MUM1 acts as an architectural component of the chromatin, which in response to DNA damage serves as an accessory factor to promote cell survival. Depletion of MUM1 or inactivation of its PWWP domain resulted in chromatin compaction. Upon DNA damage, MUM1 rapidly concentrates at the vicinity of DNA damage sites via its direct interaction with 53BP1. Ablation of this interaction impaired damage-induced chromatin decondensation, which is accompanied by sustained DNA damage and hypersensitivity to genotoxic stress. MUM1 acts as a helpful marker in the differential diagnosis of AITL(Angioimmunoblastic T cell Lymphoma with HRS-like cells and cHL.

Molekulargewicht: 78 kDa

Gen-ID: 84939

UniProt: Q2TAK8

Pathways: Chromatin Binding